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Serotonin

Serotonin

  1. Describe the biosynthesis and metabolism of serotonin.
  2. Explain the mechanism of action of triptans in the treatment of migraines.
  3. Describe the adverse effects and contraindications of triptans.
  4. Describe triptan SAR, recognize structures triptans and describe associated clinical features.
  5. Explain the proposed indication for use and mechanism of action of 5-HT1F agonists.
  6. Explain the mechanism of action of 5-HT3 receptor antagonists in the management of chemotherapy induced and post-operative nausea and vomiting.
  7. Describe the three necessary components for 5-HT3 affinity and recognize the structures of the 5-HT3 receptor antagonists.
  8. Describe the structure of the active metabolite of dolasetron.

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